Journal Publications
N. Long, A. Le Gresley, A. Wozniak, S. Brough and S. P. Wren, Synthesis and evaluation of druglike parameters via in silico techniques for a series of heterocyclic monosquarate-amide derivatives as potential carboxylic acid bioisosteres, Bioorg. Med. Chem., 2024, 98, 117565.
https://www.sciencedirect.com/science/article/pii/S0968089623004133
J. Green, R. A. J. Tinson, J. H. J. Betts, M. Piras, A. Pelut, D. Steverding, S. P. Wren, M. Searcey and L. Troeberg, Suramin analogues protect cartilage against osteoarthritic breakdown by increasing levels of tissue inhibitor of metalloproteinases 3 (TIMP-3) in the tissue, Bioorganic Med. Chem., 2023, 92, 117424.
https://www.sciencedirect.com/science/article/pii/S0968089623002729?via%3Dihub
N. Long, A. Le Gresley, A. Solomonsz, A. Wozniak, S. Brough and S. P. Wren, Synthesis of squaric acid monoamides as building blocks for drug discovery, SynOpen, 2023, 401–407.
https://www.thieme-connect.de/products/ejournals/abstract/10.1055/a-2148-951
A. M. Mostafa, S. J. Barton, S. P. Wren and J. Barker, Development of magnetic molecularly imprinted polymers for the extraction of salivary pepsin prior to analysis by a novel HPLC-SEC method, Polymer (Guildf)., 2022, 261, 125417.
https://www.sciencedirect.com/science/article/pii/S0032386122009053
I. M. Araar and S. P. Wren, A computational chemistry-driven hypothesis on the mode of action of Hipposudoric Acid and related analogs, https://doi.org/10.4155/fmc-2022-0067, , DOI:10.4155/FMC-2022-0067.
https://www.future-science.com/doi/abs/10.4155/fmc-2022-0067
A. M. Mostafa, S. J. Barton, S. P. Wren and J. Barker, Review on molecularly imprinted polymers with a focus on their application to the analysis of protein biomarkers, TrAC Trends Anal. Chem., 2021, 116431.
https://www.sciencedirect.com/science/article/pii/S0165993621002545?via%3Dihub
L. Paulsson-Habegger, A. K. Snabaitis and S. P. Wren, Enzyme Inhibition as a Potential Therapeutic Strategy to Treat COVID-19 Infection, Bioorg. Med. Chem., 2021, 48, 116389.
https://www.sciencedirect.com/science/article/pii/S0968089621003977
N. Long, A. Le Gresley and S. P. Wren, Thiazolidinediones: An In–Depth Study of Their Synthesis and Application to Medicinal Chemistry in the Treatment of Diabetes Mellitus, ChemMedChem, 2021, 16, 1716–1735.
https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cmdc.202100177
M. Benardout, A. Le Gresley, A. Elshaer and S. P. Wren, Fructose malabsorption: causes, diagnosis and treatment, Br. J. Nutr., 2022, 127, 481–489.
G. Vink, J. C. Nebel and S. P. Wren, In silico design of bioisosteric modifications of drugs for the treatment of diabetes, Future Med. Chem., 2021, 13, 691–700.
https://www.future-science.com/doi/abs/10.4155/fmc-2020-0374
J. J. Scanlon and S. P. Wren, Unearthing novel thiazolidinone building blocks as carboxylic acid bioisosteres, Future Med. Chem., 2020, 12, 1855–1864.
https://www.future-science.com/doi/abs/10.4155/fmc-2020-0192
J. Ritchie, A. Sykes, P. Weber and S. P. Wren, Immuno-oncology: The next generation of breakthrough therapies. Highlights from the Society for Medicines Research Symposium, Drugs Future, 2019, 44, 599–604.
L. A. Dawson, S. Allan, D. Brough, J. Ritchie, P. Weber and S. P. Wren, Targeting the immune system in disease. Highlights from the society for medicines research meeting, Drugs Future, 2018, 43, 289–296.
A. Chanalaris, C. Doherty, B. D. Marsden, G. Bambridge, S. P. Wren, H. Nagase and L. Troeberg, Suramin inhibits osteoarthritic cartilage degradation by increasing extracellular levels of chondroprotective tissue inhibitor of metalloproteinases 3, Mol. Pharmacol., 2017, 92, 459–468.
T. H. Nguyen, S. P. Wren, T. Sun and K. T. V. Grattan, Development of a fiber-optic chemical sensor for the detection of cadmium, Proc. IEEE Sensors, , DOI:10.1109/ICSENS.2016.7808852.
T. H. Nguyen, S. P. Wren, T. Sun and K. T. V. Grattan, in SPIE BioPhotonics Australasia, SPIE, 2016, vol. 10013, p. 100131U.
B. Thotath, T. H. Nguyen, W. Zhang, S. P. Wren, G. W. Baxter, T. Sun, S. F. Collins and K. T. V. Grattan, in 24th International Conference on Optical Fibre Sensors, SPIE, 2015, vol. 9634, p. 96344M.
C. Elosua, S. P. Wren, T. Sun, F. J. Arregui and K. T. V. Grattan, Glucose optical fibre sensor based on a luminescent molecularly imprinted polymer, 24th Int. Conf. Opt. Fibre Sensors, 2015, 9634, 963429.
T. Sun, S. Wren, H. Nguyen and K. T. V. Grattan, in ICOCN 2015 - 14th International Conference on Optical Communications and Networks, Proceedings, Institute of Electrical and Electronics Engineers Inc., 2015.
K. Zangeneh Kamali, A. Pandikumar, G. Sivaraman, H. N. Lim, S. P. Wren, T. Sun and N. M. Huang, Silver@graphene oxide nanocomposite-based optical sensor platform for biomolecules, RSC Adv., 2015, 5, 17809–17816.
https://pubs.rsc.org/en/content/articlelanding/2015/ra/c4ra11356j#!divAbstract
S. P. Wren, S. A. Piletsky, K. Karim, P. Gascoine, R. Lacey, T. Sun and K. T. V. Grattan, Computational design and fabrication of optical fibre fluorescent chemical probes for the detection of cocaine, J. Light. Technol., 2015, 33, 2572–2579.
S. P. Wren, S. A. Piletsky, K. Karim, P. Gascoine, R. Lacey, T. Sun and K. T. V. Grattan, Design and synthesis of a fluorescent molecular imprinted polymer for use in an optical fibre-based cocaine sensor, 23rd Int. Conf. Opt. Fibre Sensors, 2014, 9157, 91574W.
S. P. Wren, T. H. Nguyen, P. Gascoine, R. Lacey, T. Sun and K. T. V. Grattan, Preparation of novel optical fibre-based Cocaine sensors using a molecular imprinted polymer approach, Sensors Actuators, B Chem., 2014, 193, 35–41.
https://www.sciencedirect.com/science/article/pii/S0925400513014214?via=ihub
S. P. Wren, T. H. Nguyen, P. Gascoine, D. Lacey, T. Sun and K. T. V. Grattan, Preparation of a novel drug sensor using a molecular imprinted polymer approach, Fifth Eur. Work. Opt. Fibre Sensors, 2013, 8794, 879417.
O. De Moor, C. R. Dorgan, P. D. Johnson, A. G. Lambert, C. Lecci, C. Maillol, G. Nugent, S. D. Poignant, P. D. Price, R. J. Pye, R. Storer, J. M. Tinsley, R. Vickers, R. Van Well, F. J. Wilkes, F. X. Wilson, S. P. Wren and G. M. Wynne, Discovery and SAR of 2-arylbenzotriazoles and 2-arylindazoles as potential treatments for Duchenne muscular dystrophy, Bioorganic Med. Chem. Lett., 2011, 21, 4828–4831.
https://www.sciencedirect.com/science/article/pii/S0960894X11008304?via%3Dihub
J. M. Tinsley, R. J. Fairclough, R. Storer, F. J. Wilkes, A. C. Potter, S. E. Squire, D. S. Powell, A. Cozzoli, R. F. Capogrosso, A. Lambert, F. X. Wilson, S. P. Wren, A. de Luca and K. E. Davies, Daily treatment with SMTC1100, a novel small molecule utrophin upregulator, dramatically reduces the dystrophic symptoms in the mdx mouse, PLoS One, 2011, 6, e19189.
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0019189
D. R. Chancellor, K. E. Davies, O. De Moor, C. R. Dorgan, P. D. Johnson, A. G. Lambert, D. Lawrence, C. Lecci, C. Maillol, P. J. Middleton, G. Nugent, S. D. Poignant, A. C. Potter, P. D. Price, R. J. Pye, R. Storer, J. M. Tinsley, R. Van Well, R. Vickers, J. Vile, F. J. Wilkes, F. X. Wilson, S. P. Wren and G. M. Wynne, Discovery of 2-arylbenzoxazoles as upregulators of utrophin production for the treatment of duchenne muscular dystrophy, J. Med. Chem., 2011, 54, 3241–3250.
R. Arienzo, S. Cramp, H. J. Dyke, P. M. Lockey, D. Norman, A. G. Roach, P. Smith, M. Wong and S. P. Wren, Quinazoline and benzimidazole MCH-1R antagonists, Bioorganic Med. Chem. Lett., 2007, 17, 1403–1407.
https://www.sciencedirect.com/science/article/pii/S0960894X06013692?via%3Dihub
G. Smith, T. Ruhland, G. Mikkelsen, K. Andersen, C. T. Christoffersen, L. H. Alifrangis, A. Mørk, S. P. Wren, N. Harris, B. M. Wyman and G. Brandt, The synthesis and SAR of 2-arylsulfanyl-phenyl piperazinyl acetic acids as glyT-1 inhibitors, Bioorganic Med. Chem. Lett., 2004, 14, 4027–4030.
https://www.sciencedirect.com/science/article/pii/S0960894X04006948?via%3Dihub
R. Arienzo, D. E. Clark, S. Cramp, S. Daly, H. J. Dyke, P. Lockey, D. Norman, A. G. Roach, K. Stuttle, M. Tomlinson, M. Wong and S. P. Wren, Structure-activity relationships of a novel series of melanin-concentrating hormone (MCH) receptor antagonists, Bioorganic Med. Chem. Lett., 2004, 14, 4099–4102.
https://www.sciencedirect.com/science/article/pii/S0960894X04007012?via%3Dihub
D. E. Clark, C. Higgs, S. P. Wren, H. J. Dyke, M. Wong, D. Norman, P. M. Lockey and A. G. Roach, A virtual screening approach to finding novel and potent antagonists at the melanin-concentrating hormone 1 receptor, J. Med. Chem., 2004, 47, 3962–3971.
S. Wang, A. Folkes, I. Chuckowree, X. Cockcroft, S. Sohal, W. Miller, J. Milton, S. P. Wren, N. Vicker, P. Depledge, J. Scott, L. Smith, H. Jones, P. Mistry, R. Faint, D. Thompson and S. Cocks, Studies on Pyrrolopyrimidines as Selective Inhibitors of Multidrug-Resistance-Associated Protein in Multidrug Resistance, J. Med. Chem., 2004, 47, 1329–1338.
S. Wang, J. Golec, W. Miller, S. Milutinovic, A. Folkes, S. Williams, T. Brooks, K. Hardman, P. Charlton, S. Wren and J. Spencer, Novel inhibitors of plasminogen activator inhibitor-1: Development of new templates from diketopiperazines, Bioorganic Med. Chem. Lett., 2002, 12, 2367–2370.
https://www.sciencedirect.com/science/article/abs/pii/S0960894X0200389X?via%3Dihub
N. Vicker, L. Burgess, I. S. Chuckowree, R. Dodd, A. J. Folkes, D. J. Hardick, T. C. Hancox, W. Miller, J. Milton, S. Sohal, S. Wang, S. P. Wren, P. A. Charlton, W. Dangerfield, C. Liddle, P. Mistry, A. J. Stewart and W. A. Denny, Novel angular benzophenazines: Dual topoisomerase I and topoisomerase II inhibitors as potential anticancer agents, J. Med. Chem., 2002, 45, 721–739.
R. Carter, K. Hodgetts, J. McKenna, P. Magnus and S. Wren, Studies on the stereoselective synthesis of the marine antitumor agent Eleutherobin, Tetrahedron, 2000, 56, 4367–4382.
https://www.sciencedirect.com/science/article/abs/pii/S0040402000003094
I. Paterson and S. P. Wren, Studies towards the total synthesis of the marine-derived immunosuppressant discodermolide; asymmetric synthesis of a C1–C8 δ-lactone subunit, J. Chem. Soc., Chem. Commun., 1993, 1790–1792.
https://pubs.rsc.org/en/content/articlelanding/1993/C3/C39930001790
D. Steverding, R. A. J. Tinson, M. Piras, S. P. Wren, S. A. Rushworth, M. Searcey and L. Troeberg, Suramin: Effectiveness of analogues reveals structural features that are important for the potent trypanocidal activity of the drug, Exp. Parasitol., 2024, 108744.
https://www.sciencedirect.com/science/article/pii/S001448942400047X
A. M. Mostafa, S. J. Barton, S. P. Wren and J. Barker, Development of Highly Sensitive Fluorescent Sensors for Separation-Free Detection and Quantitation Systems of Pepsin Enzyme Applying a Structure-Guided Approach, Biosens. 2024, Vol. 14, Page 151, 2024, 14, 151.